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PQBP1 and RAB8A
Data Source:
HPRD
(two hybrid)
PQBP1
RAB8A
Description
polyglutamine binding protein 1
RAB8A, member RAS oncogene family
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoplasmic Stress Granule
Nuclear Body
Nuclear Speck
Neuronal Ribonucleoprotein Granule
Golgi Membrane
Endosome
Centrosome
Centriole
Cytosol
Plasma Membrane
Cilium
Synaptic Vesicle
Postsynaptic Density
Trans-Golgi Network Transport Vesicle
Midbody
Phagocytic Vesicle Membrane
Trans-Golgi Network Membrane
Neuronal Cell Body
Dendritic Spine
Phagocytic Vesicle
Recycling Endosome Membrane
Extracellular Exosome
Non-motile Cilium
Glutamatergic Synapse
Molecular Function
DNA Binding
Double-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Ribonucleoprotein Complex Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Kinase Binding
Small GTPase Binding
Myosin V Binding
Biological Process
Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Regulation Of Transcription, DNA-templated
Neuron Projection Development
Positive Regulation Of Type I Interferon Production
Regulation Of RNA Splicing
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Dendrite Morphogenesis
Defense Response To Virus
Cellular Response To Exogenous DsRNA
Vesicle Docking Involved In Exocytosis
Autophagy
Axonogenesis
Protein Secretion
Regulation Of Autophagy
Regulation Of Exocytosis
Cellular Response To Insulin Stimulus
Post-translational Protein Modification
Regulation Of Long-term Neuronal Synaptic Plasticity
Golgi Vesicle Fusion To Target Membrane
Regulation Of Protein Transport
Cilium Assembly
Protein Localization To Plasma Membrane
Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Neurotransmitter Receptor Transport To Postsynaptic Membrane
Vesicle-mediated Transport In Synapse
Pathways
mRNA Splicing - Major Pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Non-syndromic X-linked mental retardation
GWAS
Mean corpuscular hemoglobin (
29403010
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
27863252
)
Mean platelet volume (
32888494
27863252
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
24 interacting genes:
APBB1
APP
AQR
ATXN1
CLTB
EEF1A1
ERG28
ESR1
GOLGA2
HNRNPH2
LNX1
LRIF1
LZTS2
MAPRE1
MED31
POLR2A
POU3F2
RAB8A
RCVRN
SFTPC
TLX3
TXNL4A
WBP11
WDR77
23 interacting genes:
BAG6
BIRC6
GDI2
IKBKG
MAP4K2
MDM2
MYO5C
OCRL
ODF2
OPTN
PDE6D
PQBP1
RAB11A
RAB13
RAB3IL1
RAB3IP
RABIF
RIMS2
RPH3A
RPH3AL
SYTL1
SYTL4
TFRC
Entrez ID
10084
4218
HPRD ID
02354
01296
Ensembl ID
ENSG00000102103
ENSG00000167461
Uniprot IDs
A0A0S2Z4V5
O60828
A0A024R7I3
P61006
PDB IDs
4BWQ
4BWS
4CDO
3QBT
3TNF
4LHV
4LHW
4LHX
4LHY
4LHZ
4LI0
5SZI
6RIR
6SQ2
6STF
6STG
6ZSI
6ZSJ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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