PPIL1 and THOC5

Data Source:
BioGRID (two hybrid, two hybrid)

		PPIL1	THOC5
Description		peptidylprolyl isomerase like 1	THO complex 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Disordered Domain Specific Binding	MRNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Monocyte Differentiation MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576 29875488) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)
Interacting Genes		24 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 WDR77	11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830
Entrez ID		51645	8563
HPRD ID		03194	16650
Ensembl ID		ENSG00000137168	ENSG00000100296
Uniprot IDs		A0A024RCX8 Q9Y3C6	A0A024R1D6 Q13769
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM
Enriched GO Terms of Interacting Partners?
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