PPIL1 and PPP1R8

Data Source:
BioGRID (two hybrid, two hybrid)

		PPIL1	PPP1R8
Description		peptidylprolyl isomerase like 1	protein phosphatase 1 regulatory subunit 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Disordered Domain Specific Binding	DNA Binding RNA Binding MRNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation RNA Phosphodiester Bond Hydrolysis
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576 29875488) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)
Interacting Genes		24 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 WDR77	27 interacting genes: APP APPBP2 CDC5L CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		51645	5511
HPRD ID		03194	04028
Ensembl ID		ENSG00000137168	ENSG00000117751
Uniprot IDs		A0A024RCX8 Q9Y3C6	Q12972 Q6ICT4
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM	3V4Y
Enriched GO Terms of Interacting Partners?
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