THOC5 and LSM3

Data Source:
BioGRID (two hybrid, two hybrid)

		THOC5	LSM3
Description		THO complex 5	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	MRNA Binding Protein Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Monocyte Differentiation MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)	Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830	48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		8563	27258
HPRD ID		16650	06283
Ensembl ID		ENSG00000100296	ENSG00000170860
Uniprot IDs		A0A024R1D6 Q13769	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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