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PIK3R2 and MRFAP1L1
Data Source:
BioGRID
(two hybrid)
PIK3R2
MRFAP1L1
Description
phosphoinositide-3-kinase regulatory subunit 2
Morf4 family associated protein 1 like 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Protein Binding
Identical Protein Binding
Biological Process
Cellular Glucose Homeostasis
Phosphatidylinositol Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Protein Transport
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
Rho GTPase cycle
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Extra-nuclear estrogen signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Drugs
Isoprenaline
SF1126
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
59 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
46 interacting genes:
ABI1
ABI2
ABI3
BYSL
C1orf216
C3orf62
CAGE1
CAVIN3
CDK2AP1
CDK2AP2
CENPK
CEP44
CNOT7
CSPP1
EIF2B2
GAS8
GTF2IRD1
HGS
HTT
IHO1
LMO2
LNX1
LNX2
MEOX2
MORF4L1
MORF4L2
MRFAP1
NTAQ1
PIH1D2
PIK3R2
PSMA1
RADIL
RDM1
SDCBP
SFR1
SMARCE1
SMU1
SYCE1
TCF4
TEX11
TMEM126B
TSNAX
TXN2
UBTD1
ZDHHC17
ZNF417
Entrez ID
5296
114932
HPRD ID
04404
15162
Ensembl ID
ENSG00000105647
ENSG00000178988
Uniprot IDs
O00459
A0A075DDR2
Q96HT8
PDB IDs
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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