RHOB and PGGT1B

Data Source:
HPRD (in vitro)

		RHOB	PGGT1B
Description		ras homolog family member B	protein geranylgeranyltransferase type I subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	CAAX-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation	Positive Regulation Of Cell Population Proliferation Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways		GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Botulinum toxin type A	L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Longevity ( 30294719)
Interacting Genes		12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1	6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2
Entrez ID		388	5229
HPRD ID		01321	03612
Ensembl ID		ENSG00000143878	ENSG00000164219
Uniprot IDs		P62745	P53609
PDB IDs		2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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