RGS2 and CLTA

Data Source:
BioGRID (two hybrid)

		RGS2	CLTA
Description		regulator of G protein signaling 2	clathrin light chain A
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection	Spindle Cytosol Plasma Membrane Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Clathrin Complex Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding	Molecular_function Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding Protein-containing Complex Binding GTPase Binding
	Biological Process	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane	Intracellular Protein Transport Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Clathrin Coat Assembly Cell Division Membrane Organization Clathrin-dependent Endocytosis
Pathways		G alpha (q) signalling events	Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX	8 interacting genes: CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SYNJ1
Entrez ID		5997	1211
HPRD ID		02917	00351
Ensembl ID		ENSG00000116741	ENSG00000122705
Uniprot IDs		A0A024R939 P41220	C9J8P9 P09496
PDB IDs		2AF0 2V4Z 4EKC 4EKD	6E5N
Enriched GO Terms of Interacting Partners?
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