CARD9 and LENG1

Data Source:
BioGRID (two hybrid)

		CARD9	LENG1
Description		caspase recruitment domain family member 9	leukocyte receptor cluster member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Cellular_component
	Molecular Function	Protein Binding Protein Homodimerization Activity CARD Domain Binding	Molecular_function Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus	Biological_process
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)	Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		138 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CABP2 CARD10 CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DISC1 DUSP13 DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GAS8 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TEX33 TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	84 interacting genes: ABI2 APP ASB12 BANP BEGAIN C14orf119 CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCHCR1 CDR2 CDR2L CEP57L1 CEP70 DDIT4L DES DISC1 EVI5 FSD2 GFAP GOLGA2 GOLGA6L9 HOMEZ HOOK2 IKZF3 ISY1-RAB43 KANK2 KASH5 KIFC3 KLF10 KRT19 KRT31 KRT35 KRT40 KRTAP10-8 LDOC1 LRP2BP LZTS1 MAB21L3 MAD1L1 MEIS3 MID2 MIPOL1 MRPL28 MTUS2 NAB2 NAGK NECAB2 NTAQ1 NUTF2 OIP5 OSGEP PAK5 PDE4DIP PNMA1 PRKAR1B PRPH PSMB1 RABEP1 REL ROPN1 SCYL1 SPATA2 STX11 TCF4 TEPSIN TEX12 TFIP11 TMEM239 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC1 UBL5 UBXN11 USHBP1 ZMYND12 ZRANB1
Entrez ID		64170	79165
HPRD ID		06236	13985
Ensembl ID		ENSG00000187796	ENSG00000105617
Uniprot IDs		A0A024R8F1 Q9H257	Q96BZ8
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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