TLX3 and MEIS1

Data Source:
HPRD (in vitro)

		TLX3	MEIS1
Description		T cell leukemia homeobox 3	Meis homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of Transcription By RNA Polymerase II Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body size at age 10 ( 32376654)	Adolescent idiopathic scoliosis ( 28334814) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Insomnia ( 27992416 32332799) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) PR interval ( 30679814 30046033 32439900 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		106 interacting genes: ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C11orf1 C11orf45 C19orf54 C2orf42 CEACAM6 CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM166B FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 TEX37 THTPA TLE1 TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		30012	4211
HPRD ID		06868	03442
Ensembl ID		ENSG00000164438	ENSG00000143995
Uniprot IDs		O43711	O00470
PDB IDs			4XRS 5EGO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?