NPC1 and VPS4A

Data Source:
BioGRID (pull down)

		NPC1	VPS4A
Description		NPC intracellular cholesterol transporter 1	vacuolar protein sorting 4 homolog A
Image
GO Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Integral Component Of Lysosomal Membrane	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Sterol Transporter Activity Cholesterol Binding Signaling Receptor Activity	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding
	Biological Process	Protein Glycosylation Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Cholesterol Metabolic Process Bile Acid Metabolic Process Negative Regulation Of Macroautophagy Cholesterol Transport Membrane Raft Organization Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Response To Drug Cholesterol Homeostasis Response To Cadmium Ion Viral Entry Into Host Cell Negative Regulation Of Cell Death Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly
Pathways		LDL clearance	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) White blood cell count ( 27863252)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		5 interacting genes: BUD31 GPR35 MC4R MTDH VPS4A	10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B
Entrez ID		4864	27183
HPRD ID		09622	11676
Ensembl ID		ENSG00000141458	ENSG00000132612
Uniprot IDs		O15118	A0A024R705 Q9UN37
PDB IDs		3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V	1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?
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