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CCN3 and IGF2
Data Source:
HPRD
(in vitro)
CCN3
IGF2
Description
cellular communication network factor 3
insulin like growth factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Gap Junction
Axon
Dendrite
Extracellular Matrix
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Extracellular Region
Extracellular Space
Platelet Alpha Granule Lumen
Molecular Function
Notch Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Growth Factor Activity
Heparin Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Protein Serine/threonine Kinase Activator Activity
Receptor Ligand Activity
Biological Process
Angiogenesis
Chondrocyte Differentiation
Cell Adhesion
Signal Transduction
Regulation Of Gene Expression
Fibroblast Migration
Negative Regulation Of Myotube Differentiation
Smooth Muscle Cell Migration
Negative Regulation Of Cell Growth
Cell Adhesion Mediated By Integrin
Endothelial Cell Chemotaxis
Type B Pancreatic Cell Proliferation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Insulin Secretion
Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Cell Death
Hematopoietic Stem Cell Homeostasis
Endothelial Cell-cell Adhesion
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Sensory Perception Of Pain
Bone Regeneration
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Osteoblast Differentiation
In Utero Embryonic Development
Embryonic Placenta Development
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Glucose Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription, DNA-templated
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Exocrine Pancreas Development
Regulation Of Histone Modification
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Catalytic Activity
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Positive Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Skeletal Muscle Tissue Growth
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Striated Muscle Cell Differentiation
Regulation Of Muscle Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Embryonic Placenta Morphogenesis
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Insulin pork
Diseases
Beckwith-Wiedemann syndrome
Russell-Silver syndrome; Silver-Russell syndrome
Adrenal carcinoma
GWAS
Birth weight (
27680694
)
Celiac disease (
23936387
)
Creatinine levels (
29403010
)
DNA methylation (variation) (
23725790
)
Estimated glomerular filtration rate (
31015462
30604766
)
Femoral neck bone geometry and menarche (age at onset) (
23593202
)
Glomerular filtration rate (
29403010
)
Length of menstrual cycle (
30202859
)
Periventricular white matter hyperintensities (
32517579
)
Prostate cancer (
19767753
)
Pursuit maintenance gain (
29064472
)
Type 2 diabetes (
30297969
32499647
30718926
)
Urate levels (
31578528
)
Interacting Genes
29 interacting genes:
ADSL
ANKRD11
APOL6
C11orf87
CCN2
CDKN1A
COL8A1
DLL1
FAM90A1
FBLN1
FN1
FRS3
GJA1
HOXA1
IGF1
IGF2
INS
ITGAV
KRTAP5-6
LCE1A
LCE3D
NID2
NOTCH1
POLR2L
POU4F2
RECK
S100A4
TNIP3
ZNF330
26 interacting genes:
BAG6
CCN3
CCN5
CLN5
FAF1
GPC3
GPR152
IDE
IGF1R
IGF2R
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
INSR
NMRK2
PCSK4
PLG
RBPMS
TF
TRIM55
TRIM63
VTN
Entrez ID
4856
3481
HPRD ID
01291
00939
Ensembl ID
ENSG00000136999
ENSG00000167244
Uniprot IDs
A0A024R9J4
P48745
E3UN46
P01344
PDB IDs
1GF2
1IGL
2L29
2V5P
3E4Z
3KR3
5L3L
5L3M
5L3N
6UM2
6VWG
6VWI
Enriched GO Terms of Interacting Partners
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