IGF2 and IGFBP2

Data Source:
HPRD (in vivo, in vitro)

		IGF2	IGFBP2
Description		insulin like growth factor 2	insulin like growth factor binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Regulation Of Histone Modification Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Embryonic Placenta Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Glycogen (starch) Synthase Activity	Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Growth Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Cellular Protein Metabolic Process Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases		Beckwith-Wiedemann syndrome Russell-Silver syndrome; Silver-Russell syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 32499647 30718926) Urate levels ( 31578528)	Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)
Interacting Genes		26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN	6 interacting genes: GSDMB IGF1 IGF2 INO80B KLK2 TF
Entrez ID		3481	3485
HPRD ID		00939	00898
Ensembl ID		ENSG00000167244	ENSG00000115457
Uniprot IDs		E3UN46 P01344	C9JMY1 P18065
PDB IDs		1GF2 1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI	2H7T
Enriched GO Terms of Interacting Partners?
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