IGF2 and IGFBP7

Data Source:
HPRD (in vitro)

		IGF2	IGFBP7
Description		insulin like growth factor 2	insulin like growth factor binding protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Regulation Of Histone Modification Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Embryonic Placenta Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Heat Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Insulin pork
Diseases		Beckwith-Wiedemann syndrome Russell-Silver syndrome; Silver-Russell syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 32499647 30718926) Urate levels ( 31578528)	Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN	11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		3481	3490
HPRD ID		00939	04183
Ensembl ID		ENSG00000167244	ENSG00000163453
Uniprot IDs		E3UN46 P01344	Q16270
PDB IDs		1GF2 1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI
Enriched GO Terms of Interacting Partners?
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