NGF and CRYAB

Data Source:
BioGRID (unspecified method)

		NGF	CRYAB
Description		nerve growth factor	crystallin alpha B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Activation Of MAPKK Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Memory Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Nerve Development Nerve Growth Factor Processing Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	HSF1-dependent transactivation
Drugs		Clenbuterol RI 624 Polaprezinc
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Red blood cell count ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)	Birth weight ( 31043758) PR interval ( 32439900)
Interacting Genes		11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1	54 interacting genes: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYAA2 CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		4803	1410
HPRD ID		08874	00428
Ensembl ID		ENSG00000134259	ENSG00000109846
Uniprot IDs		A0A346FYQ1 P01138	A0A024R3B9 P02511 V9HW27
PDB IDs		1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9
Enriched GO Terms of Interacting Partners?
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