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NDUFS6 and MAPK6
Data Source:
BioGRID
(two hybrid)
NDUFS6
MAPK6
Description
NADH:ubiquinone oxidoreductase subunit S6
mitogen-activated protein kinase 6
Image
GO Annotations
Cellular Component
Mitochondrial Inner Membrane
Mitochondrial Respiratory Chain Complex I
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
NADH Dehydrogenase (ubiquinone) Activity
Electron Transfer Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
Mitochondrial Electron Transport, NADH To Ubiquinone
Mitochondrial Respiratory Chain Complex I Assembly
MAPK Cascade
Protein Phosphorylation
Cell Cycle
Signal Transduction
Intracellular Signal Transduction
Pathways
Respiratory electron transport
Complex I biogenesis
MAPK6/MAPK4 signaling
Drugs
NADH
Acetylsalicylic acid
Minocycline
Diseases
Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Lack of perseverance (
30718321
)
Metabolite levels (
23823483
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Interacting Genes
5 interacting genes:
FGFR3
KCNH2
MAP3K7
MAPK6
MAPK8IP2
166 interacting genes:
ACTG1
ACTR1B
AMPH
ANAPC5
ANK3
ANKRD2
APBA2
ARHGDIA
ARPC3
ATG9A
ATP5PF
BAG6
BARX1
BBS10
CA1
CA12
CALR
CASP6
CCND3
CCT3
CDH13
CERS1
CFAP298
CFL1
CNTN1
CNTRL
COPS6
CSE1L
CYRIB
CYTH2
DBN1
DCTN2
DDOST
DDR1
DGKZ
DKC1
DNAJC28
DPPA4
DST
DYNC2I2
EDF1
EEF1A2
EIF1
EIF3C
EIF4A1
ELOF1
EMD
FBXL16
FOXO3
FXYD3
GALNT7
GATA1
GLRX3
GORASP1
GPX1
HACL1
HAUS2
HDAC11
HIP1
HNRNPA0
HNRNPD
HNRNPH3
HSP90AB1
HSP90B1
HSPD1
IDH3B
INS
ITGB3BP
ITSN1
JUNB
KDSR
KLC1
KNSTRN
LPXN
MAP3K12
MAP3K7
MAPKAPK5
MASP1
MBIP
MBOAT7
MCM3
MDK
METTL17
METTL2A
MGAT1
MIPEP
MOK
MON1A
MTG2
MYBL2
MYOZ3
MZB1
NAT9
NAXE
NDUFS6
NECTIN2
NELFB
NOL4
NRXN2
NUDT5
OSTF1
PDCD6IP
PDLIM1
PHACTR3
PHC2
PHGDH
PIH1D1
PLEKHM1
PLSCR1
PPBP
PPP1R7
PPP2R1A
PRKAB1
PRKAR1A
PRKCB
PRPF38A
PSAT1
PSIP1
PTPMT1
RAB2A
RAB31
RACK1
RANBP9
RAP1GAP
RARA
RBL1
RGS19
RPL10
RRP7A
SEPTIN3
SEPTIN5
SERPINA4
SHC1
SLC20A1
SLC41A3
SMAD6
SMS
SNAPC4
SNW1
SOCS3
SPG7
SPRR2D
SPTAN1
SRSF5
STX7
TDP2
THAP4
TPI1
TTK
TUBA1A
UBA52
UBE2L3
URB1
USP20
VPS26C
WDR26
WFS1
WWC1
XPO1
ZNF133
ZNF205
ZNF331
ZNF579
ZNF600
ZNF671
ZNF775
Entrez ID
4726
5597
HPRD ID
10356
04213
Ensembl ID
ENSG00000145494
ENSG00000069956
Uniprot IDs
O75380
Q6IBC4
Q16659
PDB IDs
5XTB
5XTD
5XTH
5XTI
6YKY
6YLC
6YLL
7AQB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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