ENO3 and PKM

Data Source:
BioGRID (two hybrid, biochemical)

		ENO3	PKM
Description		enolase 3	pyruvate kinase M1/2
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GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Pyruvate Kinase Complex Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Identical Protein Binding Protein-containing Complex Binding	Magnesium Ion Binding RNA Binding MRNA Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Identical Protein Binding ADP Binding Cadherin Binding Thyroid Hormone Binding
	Biological Process	Gluconeogenesis Glycolytic Process Aging Regulation Of Vacuole Fusion, Non-autophagic Response To Drug Skeletal Muscle Tissue Regeneration Canonical Glycolysis	Response To Hypoxia Liver Development Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Gravity Programmed Cell Death Response To Muscle Inactivity Animal Organ Regeneration Cellular Response To Insulin Stimulus Pyruvate Biosynthetic Process Neutrophil Degranulation Skeletal Muscle Tissue Regeneration Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways		Glycolysis Gluconeogenesis	Neutrophil degranulation
Drugs		2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid	Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Copper Artenimol
Diseases
GWAS		Red cell distribution width ( 32888494)
Interacting Genes		20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN	55 interacting genes: ANXA7 APP ARAF AURKB CCR4 CDC25A CDK4 CDKN1A CTNNB1 DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 GRB7 HERC1 HIF1A HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MDM2 MYL2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 SUMO1 SUMO2 TERF1 TINF2 TK1 TRIM35 TRIM55 TRIM63 UCHL5 YWHAQ
Entrez ID		2027	5315
HPRD ID		11746	01529
Ensembl ID		ENSG00000108515	ENSG00000067225
Uniprot IDs		P13929	A0A024R5Z9 B4DNK4 P14618 V9HWB8
PDB IDs		2XSX	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6
Enriched GO Terms of Interacting Partners?
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