NARS1 and LSM1

Data Source:
HPRD (two hybrid)

		NARS1	LSM1
Description		asparaginyl-tRNA synthetase 1	LSM1 homolog, mRNA degradation associated
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Axon Dendrite Neuronal Cell Body Messenger Ribonucleoprotein Complex Lsm1-7-Pat1 Complex
	Molecular Function	Nucleic Acid Binding Asparagine-tRNA Ligase Activity Protein Binding ATP Binding CCR3 Chemokine Receptor Binding Protein Dimerization Activity	RNA Cap Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Asparaginyl-tRNA Aminoacylation Cell Migration	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Metabolic Process Stem Cell Population Maintenance Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process
Pathways		Cytosolic tRNA aminoacylation	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs		Asparagine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 22037555 29483656)
Interacting Genes		4 interacting genes: ATXN1 HSPB2 LSM1 SUMO2	32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11
Entrez ID		4677	27257
HPRD ID		00154	06281
Ensembl ID		ENSG00000134440	ENSG00000175324
Uniprot IDs		O43776	A0A0S2Z590 O15116
PDB IDs		4ZYA 5XIX
Enriched GO Terms of Interacting Partners?
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