NACA and IGSF21

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NACA	IGSF21
Description		nascent polypeptide associated complex subunit alpha	immunoglobin superfamily member 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nascent Polypeptide-associated Complex	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	DNA Binding Unfolded Protein Binding
	Biological Process	Protein Targeting To Membrane	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474) Atrial fibrillation ( 30061737 29892015) Diastolic blood pressure ( 30224653) JT interval ( 29874175) QRS duration ( 30012220)	Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		17 interacting genes: APLP1 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 PPP1R18 PTEN SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		4666	84966
HPRD ID		03137	11309
Ensembl ID		ENSG00000196531	ENSG00000117154
Uniprot IDs		A0A024RB41 Q13765	Q96ID5
PDB IDs		3LKX 3MCB 3MCE
Enriched GO Terms of Interacting Partners?
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