PPP1R12A and ATXN10

Data Source:
BioGRID (two hybrid)

		PPP1R12A	ATXN10
Description		protein phosphatase 1 regulatory subunit 12A	ataxin 10
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	Protein Binding Enzyme Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Cellular Response To Drug Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Endothelial Barrier	Nervous System Development Neuron Projection Development Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference ( 28552196) Waist circumference ( 28552196)
Interacting Genes		14 interacting genes: ATXN10 CDKN3 DMPK IL16 ILF3 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG	12 interacting genes: ABCA1 FN1 GLS GNB1 GNB2 GOLGA1 HSPB1 HTR6 LIMS1 MRPS16 PPP1R12A PTGER4
Entrez ID		4659	25814
HPRD ID		03606	04624
Ensembl ID		ENSG00000058272	ENSG00000130638
Uniprot IDs		B2RAH5 O14974	Q9UBB4
PDB IDs		2KJY 5HUZ
Enriched GO Terms of Interacting Partners?
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