PPP1R12A and ROCK2

Data Source:
HPRD (in vitro)

		PPP1R12A	ROCK2
Description		protein phosphatase 1 regulatory subunit 12A	Rho associated coiled-coil containing protein kinase 2
Image
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	RNA Binding Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Cellular Response To Drug Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Endothelial Barrier	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Response To Ischemia Aortic Valve Morphogenesis Protein Phosphorylation Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Rho Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Regulation Of Nervous System Process Positive Regulation Of Connective Tissue Growth Factor Production Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Myosin-light-chain-phosphatase Activity Viral RNA Genome Replication Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Embryonic Morphogenesis Regulation Of Protein Metabolic Process Centrosome Duplication Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Cellular Response To Testosterone Stimulus Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Positive Regulation Of Fibroblast Growth Factor Production Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Regulation Of Cellular Response To Hypoxia Regulation Of Cell Junction Assembly Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Cellular Response To Acetylcholine Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHOBTB1 GTPase cycle Potential therapeutics for SARS
Drugs			Fasudil Y-27632 Fostamatinib Ripasudil Netarsudil
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494)
Interacting Genes		14 interacting genes: ATXN10 CDKN3 DMPK IL16 ILF3 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG	5 interacting genes: CDKN3 MAGEC1 PPP1R12A PTPRF STAU1
Entrez ID		4659	9475
HPRD ID		03606	04922
Ensembl ID		ENSG00000058272	ENSG00000134318
Uniprot IDs		B2RAH5 O14974	A0A2P9DU05 O75116 Q14DU5
PDB IDs		2KJY 5HUZ	4L6Q 4WOT 5U7Q 5U7R 6ED6 6P5M 6P5P 7JNT 7JOV
Enriched GO Terms of Interacting Partners?
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