MT-CO2 and RAD21

Data Source:
BioGRID (two hybrid)

		MT-CO2	RAD21
Description		cytochrome c oxidase subunit II	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Integral Component Of Membrane Respiratory Chain Complex IV	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Cytochrome-c Oxidase Activity Copper Ion Binding Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Mitochondrial Electron Transport, Cytochrome C To Oxygen Lactation Response To Cold Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Necrotic Cell Death ATP Synthesis Coupled Electron Transport Proton Transmembrane Transport Positive Regulation Of ATP Biosynthetic Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs		Cholic Acid N-Formylmethionine Talmapimod
Diseases
GWAS			Menopause (age at onset) ( 29773799)
Interacting Genes		9 interacting genes: CCNG1 ECT2 EGFR HSPB2 LIG4 PSMA1 RAD21 RIDA YWHAE	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		4513	5885
HPRD ID		02470	05924
Ensembl ID		ENSG00000198712	ENSG00000164754
Uniprot IDs		A0A1X7RBF7 P00403 U5Z487	A0A024R9J0 O60216
PDB IDs		3VRJ 5Z62	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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