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ASPH and PDGFA
Data Source:
BioGRID
(two hybrid)
ASPH
PDGFA
Description
aspartate beta-hydroxylase
platelet derived growth factor subunit A
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Membrane
Cortical Endoplasmic Reticulum
Sarcoplasmic Reticulum Membrane
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Microvillus
Cell Surface
Platelet Alpha Granule Lumen
Molecular Function
Peptide-aspartate Beta-dioxygenase Activity
Structural Molecule Activity
Calcium Ion Binding
Protein Binding
Structural Constituent Of Muscle
Electron Transfer Activity
Peptidyl-aspartic Acid 3-dioxygenase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Biological Process
Muscle Contraction
Protein Phosphopantetheinylation
Electron Transport Chain
Ion Transmembrane Transport
Peptidyl-aspartic Acid Hydroxylation
Positive Regulation Of Proteolysis
Activation Of Cysteine-type Endopeptidase Activity
Regulation Of Cardiac Conduction
MAPK Cascade
Angiogenesis
Cell Activation
Hair Follicle Development
Positive Regulation Of Mesenchymal Cell Proliferation
Platelet Degranulation
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Smooth Muscle Cell Migration
Cell Projection Assembly
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Wound Healing
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Skin Development
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Glomerular Mesangial Cell Proliferation
Embryonic Lung Development
Regulation Of DNA Biosynthetic Process
Pathways
Stimuli-sensing channels
Ion homeostasis
Non-integrin membrane-ECM interactions
Drugs
Aspartic acid
Diseases
Malignant pleural mesothelioma
Glioma
GWAS
Blood protein levels (
30072576
29875488
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Resting heart rate (
28270201
)
Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome (
31991592
)
Urate levels in overweight individuals (
25811787
)
Male-pattern baldness (
28196072
)
Interacting Genes
71 interacting genes:
AGR2
APP
BGLAP
CDSN
CHRM5
CST1
CTSA
CXorf66
DCD
DEFB1
DHRSX
ENPP6
FBXO7
FDCSP
FGFBP1
FKBP7
GAL
GAST
GET3
GOLM1
GPR119
GPX7
GPX8
GSC2
GUCA2A
IL21
INSL5
KCNIP1
KCNIP3
KCNIP4
LCN2
LRPAP1
LTA
NUCB2
OCIAD1
PCSK4
PDGFA
PDGFRL
PLAAT2
PLEKHF2
PRAP1
PRB1
PRB2
PRB4
PRH1
PTH
PTN
RCN1
RELL2
RNASEH1
SCGB1C2
SDC2
SF3A2
SGTB
SHISAL1
SLC51B
SMIM11A
SMIM11B
SMIM19
SOD3
SPINK1
TMEM167B
TMX2
TNFRSF10B
TRDN
TUFM
TXNDC15
UGT2B11
WFDC12
WFDC5
ZG16
17 interacting genes:
A2M
ASPH
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
DUSP3
FURIN
HSPG2
MBD3
MDFI
PDAP1
PDGFRA
SPARC
Entrez ID
444
5154
HPRD ID
08996
01424
Ensembl ID
ENSG00000198363
ENSG00000197461
Uniprot IDs
B4DQ07
B7ZM96
Q12797
P04085
PDB IDs
5APA
5JQY
5JTC
5JZ6
5JZ8
5JZA
5JZU
6Q9F
6Q9I
6QA5
6RK9
3MJK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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