KRTAP5-7 and IGFBP6

Data Source:
BioGRID (two hybrid)

		KRTAP5-7	IGFBP6
Description		keratin associated protein 5-7	insulin like growth factor binding protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Protein Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Keratinization	Activation Of MAPK Activity Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Keratinization	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS			Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		61 interacting genes: ADAMTSL3 ADAMTSL4 CARD9 CD300LG COL8A1 CRCT1 CREB5 CRY2 CYSRT1 DMRT3 DOCK2 FAM161A GUCD1 HHEX HOXB9 IGFBP6 IGSF8 IL2RG ITGB5 KPRP KRTAP10-1 KRTAP10-10 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-6 KRTAP9-2 LCE1A LCE1B LCE1E LCE2B LCE2C LCE2D LCE3A LCE3B LCE3D LCE3E LCE4A MACO1 MAPKBP1 MRGBP MXI1 MYOM1 PHLDA1 PTPMT1 RAMP3 SAMD11 SCARF1 SDC3 SHFL SLC39A7 SPATA3 TRIM42 UXT WNT11 ZNF330 ZNF440 ZNF479 ZNF587 ZNF613	37 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 EFEMP1 EFEMP2 ENKD1 EPDR1 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		440050	3489
HPRD ID		17251	00902
Ensembl ID		ENSG00000244411	ENSG00000167779
Uniprot IDs		Q6L8G8	P24592
PDB IDs			1RMJ
Enriched GO Terms of Interacting Partners?
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