MMP7 and HAPLN1

Data Source:
HPRD (in vitro)

		MMP7	HAPLN1
Description		matrix metallopeptidase 7	hyaluronan and proteoglycan link protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Matrix Synapse Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Aging Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Response To Nutrient Levels Estrous Cycle Maternal Process Involved In Female Pregnancy Cellular Response To Mechanical Stimulus	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling	ECM proteoglycans
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID	Hyaluronic acid
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)	Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN
Entrez ID		4316	1404
HPRD ID		01525	00275
Ensembl ID		ENSG00000137673	ENSG00000145681
Uniprot IDs		P09237	A0A024RAK9 P10915
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5
Enriched GO Terms of Interacting Partners?
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