HAPLN1 and ACAN

Data Source:
HPRD (in vitro)

		HAPLN1	ACAN
Description		hyaluronan and proteoglycan link protein 1	aggrecan
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Synapse Collagen-containing Extracellular Matrix	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Keratan Sulfate Catabolic Process
Pathways		ECM proteoglycans	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Hyaluronic acid	Ilomastat
Diseases			Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR
Entrez ID		1404	176
HPRD ID		00275	01123
Ensembl ID		ENSG00000145681	ENSG00000157766
Uniprot IDs		A0A024RAK9 P10915	P16112
PDB IDs			4MD4
Enriched GO Terms of Interacting Partners?
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