HAPLN1 and VCAN

Data Source:
HPRD (in vitro)

		HAPLN1	VCAN
Description		hyaluronan and proteoglycan link protein 1	versican
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Synapse Collagen-containing Extracellular Matrix	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		ECM proteoglycans	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs		Hyaluronic acid	Hyaluronic acid
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness (mean) ( 31801372) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348) White matter integrity (fractional anisotropy) ( 29752348 32358547) White matter integrity (mean diffusivity) ( 29752348 32358547)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		1404	1462
HPRD ID		00275	00340
Ensembl ID		ENSG00000145681	ENSG00000038427
Uniprot IDs		A0A024RAK9 P10915	A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs
Enriched GO Terms of Interacting Partners?
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