MMP7 and BCAN

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MMP7	BCAN
Description		matrix metallopeptidase 7	brevican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Extracellular Exosome	Extracellular Region Golgi Lumen Extracellular Matrix Anchored Component Of Membrane Lysosomal Lumen Glutamatergic Synapse
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Aging Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Response To Nutrient Levels Estrous Cycle Maternal Process Involved In Female Pregnancy Cellular Response To Mechanical Stimulus	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Synapse Maturation
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling	Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)	Blood protein levels ( 30072576 29875488)
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		4316	63827
HPRD ID		01525	02644
Ensembl ID		ENSG00000137673	ENSG00000132692
Uniprot IDs		P09237	Q96GW7
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5
Enriched GO Terms of Interacting Partners?
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