HAPLN1 and MMP3

Data Source:
HPRD (in vitro)

		HAPLN1	MMP3
Description		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Synapse Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Proteolysis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV-A Cellular Response To Nitric Oxide Regulation Of Neuroinflammatory Response Positive Regulation Of Oxidative Stress-induced Cell Death Response To Amyloid-beta
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Hyaluronic acid	Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 4-methoxybenzenesulfinate 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Alzheimer's disease ( 22832961) Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Peripheral artery disease ( 31285632) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	19 interacting genes: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 MMP14 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11
Entrez ID		1404	4314
HPRD ID		00275	01703
Ensembl ID		ENSG00000145681	ENSG00000149968
Uniprot IDs		A0A024RAK9 P10915	P08254
PDB IDs			1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1M1W 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1 6MAV 6N9D
Enriched GO Terms of Interacting Partners?
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