MAP3K10 and CNKSR1

Data Source:
HPRD (in vivo)

		MAP3K10	CNKSR1
Description		mitogen-activated protein kinase kinase kinase 10	connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways			MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		4294	10256
HPRD ID		02533	11937
Ensembl ID		ENSG00000130758	ENSG00000142675
Uniprot IDs		Q02779	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		2RF0	1WWV
Enriched GO Terms of Interacting Partners?
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