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MKI67 and CDK1
Data Source:
BioGRID
(enzymatic study)
MKI67
CDK1
Description
marker of proliferation Ki-67
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Condensed Chromosome
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Membrane
Nuclear Body
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Molecular Function
DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Biological Process
Cell Cycle
Regulation Of Mitotic Nuclear Division
Cell Population Proliferation
Regulation Of Chromosome Segregation
Regulation Of Chromatin Organization
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Epithelial Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Embryonic Development
Viral Entry Into Host Cell
Rhythmic Process
Cell Division
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Diseases
GWAS
Alzheimer's disease in APOE e4- carriers (
25778476
)
Drug experimentation measurement (
30718321
)
Lead levels (
26025379
)
Select biomarker traits (
17903293
)
Triglyceride levels x loop diuretics use interaction (
31806883
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
14 interacting genes:
CBX3
CBX5
CDK1
ECPAS
HINFP
KIF15
NIFK
PRKCB
PTEN
SMN1
SUMO2
TK1
TRIM55
TRIM63
186 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
Entrez ID
4288
983
HPRD ID
08902
00302
Ensembl ID
ENSG00000148773
ENSG00000170312
Uniprot IDs
P46013
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
PDB IDs
1R21
2AFF
5J28
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
Enriched GO Terms of Interacting Partners
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