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MET and TNS2
Data Source:
BioGRID
(pull down)
MET
TNS2
Description
MET proto-oncogene, receptor tyrosine kinase
tensin 2
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Cell Surface
Integral Component Of Membrane
Receptor Complex
Plasma Membrane
Focal Adhesion
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Hepatocyte Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Semaphorin Receptor Activity
Protein Phosphatase Binding
Identical Protein Binding
Protein Tyrosine Phosphatase Activity
Protein Binding
Kinase Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
MAPK Cascade
Endothelial Cell Morphogenesis
Liver Development
Phagocytosis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Negative Regulation Of Autophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Pancreas Development
Positive Regulation Of Microtubule Polymerization
Positive Regulation Of Kinase Activity
Negative Regulation Of Rho Protein Signal Transduction
Entry Of Bacterium Into Host Cell
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Positive Chemotaxis
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Establishment Of Skin Barrier
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Semaphorin-plexin Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Positive Regulation Of Endothelial Cell Chemotaxis
Kidney Development
Negative Regulation Of Cell Population Proliferation
Response To Muscle Activity
Cellular Homeostasis
Collagen Metabolic Process
Multicellular Organism Growth
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Negative Regulation Of Insulin Receptor Signaling Pathway
Multicellular Organismal Homeostasis
Pathways
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Drugs
K-252a
SGX-523
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
AMG-208
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
Crizotinib
Cabozantinib
Capmatinib
Fostamatinib
Tivantinib
Brigatinib
Amuvatinib
Diseases
Renal cell carcinoma
Cholangiocarcinoma
Gastric cancer
GWAS
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
)
HDL cholesterol levels (
28334899
)
Hematocrit (
28017375
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (beta blocking agents) (
31015401
)
Multiple sclerosis (severity) (
19010793
)
PR segment (
24850809
)
Pulse pressure (
30578418
)
Resting heart rate (
29769521
27798624
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
112 interacting genes:
ABL2
BAG1
BCAR3
BLK
BTK
CASP3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2B
CNR1
CRK
CTNNB1
CTTN
DAPK3
DCN
DNAJA3
EGFR
EPHA2
ERBB2
FAS
FES
FGFR4
FGR
FZR1
GAB1
GLIS2
GLMN
GRB14
GRB2
GRB7
HCK
HGF
HGS
HSH2D
INPP5D
INPPL1
ITGB1
ITGB4
ITK
KDELR2
LATS2
LCK
LYN
MAP2K3
MAP2K5
MATK
MUC20
MYC
NCK1
NCK2
NF2
PCBD2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PLXNB1
PTK6
PTPN11
PTPRB
PTPRJ
RAF1
RANBP10
RANBP9
RASA1
RASSF1
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA2
SMC1A
SNAPIN
SNX2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPSB1
SRC
STAP1
STAT3
STK11
SYK
TEC
TERT
TNS1
TNS2
TNS3
TNS4
TP53
TXK
VAV1
VAV2
VAV3
YES1
ZAP70
150 interacting genes:
ADCK5
AMMECR1
AP1S2
AQP1
ARID5A
ASB3
AXL
BAHD1
BLZF1
BRCA1
C11orf87
C1orf94
CATSPER1
CCDC33
CNNM3
COX6B2
CPSF7
CRX
CSNK1E
CTSZ
DCAF11
DCAF8
DDIT4L
DLC1
DOK3
DZIP1
DZIP3
EGFR
ENKD1
EPB41L4A
EPDR1
EPS8L2
ERBB2
ERBB3
ERBB4
FABP7
FAM114A1
FAM228A
FASLG
FGF21
FGFR1
FOXO1
GATA1
GBA3
GFI1B
HOXA1
HOXB9
HOXC8
HUWE1
ID2
IHO1
INO80B
ITGB3
ITGB5
ITGB7
KCTD9
KIF1A
KIT
KPRP
KRT76
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP12-3
KRTAP13-1
KRTAP13-2
KRTAP23-1
KRTAP3-1
KRTAP4-4
KRTAP6-3
LASP1
LPXN
LUZP4
MET
MGAT5B
MPEG1
MT2A
MTDH
MYBPHL
MYH7B
MYPOP
NBPF19
NMU
NOTCH2NLA
NT5C
NUBP2
OBSL1
OTX1
PATZ1
PER1
PHF1
PIN1
PKP1
PLB1
PLK3
PLSCR3
POLR1H
POLR3F
PRR22
RAMAC
RBAK
RBPMS
REEP6
REL
RFT1
RNF6
SDCCAG8
SERTAD2
SH2B3
SHFL
SOCS7
SORBS3
SPATA12
SPRY2
SPRY4
SUSD2
SUV39H1
TBC1D16
TCP10L
TEKT3
TEKT5
TENT5A
TENT5B
TFAP2D
TLE5
TM4SF19
TRIM8
TSC1
TWSG1
USP54
WAC
WDFY3
ZCCHC14
ZIM2
ZNF134
ZNF205
ZNF250
ZNF417
ZNF497
ZNF575
ZNF586
ZNF587
ZNF648
ZNF655
ZNF688
ZNF837
Entrez ID
4233
23371
HPRD ID
01280
16256
Ensembl ID
ENSG00000105976
ENSG00000111077
Uniprot IDs
A0A024R728
A0A024R759
B4DLF5
E6Y365
P08581
A0A024RB48
Q63HR2
PDB IDs
1FYR
1R0P
1R1W
1SHY
1SSL
1UX3
2G15
2RFN
2RFS
2UZX
2UZY
2WD1
2WGJ
2WKM
3A4P
3BUX
3C1X
3CCN
3CD8
3CE3
3CTH
3CTJ
3DKC
3DKF
3DKG
3EFJ
3EFK
3F66
3F82
3I5N
3L8V
3LQ8
3Q6U
3Q6W
3QTI
3R7O
3RHK
3U6H
3U6I
3VW8
3ZBX
3ZC5
3ZCL
3ZXZ
3ZZE
4AOI
4AP7
4DEG
4DEH
4DEI
4EEV
4GG5
4GG7
4IWD
4K3J
4KNB
4MXC
4O3T
4O3U
4R1V
4R1Y
4XMO
4XYF
5DG5
5EOB
5EYC
5EYD
5HLW
5HNI
5HO6
5HOA
5HOR
5HTI
5LSP
5T3Q
5UAB
5UAD
5YA5
6GCU
6I04
6SD9
6SDC
6SDD
6SDE
6UBW
2DKQ
2KNO
2L6K
2LOZ
3HQC
Enriched GO Terms of Interacting Partners
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