MEIS2 and DGCR6

Data Source:
BioGRID (two hybrid)

		MEIS2	DGCR6
Description		Meis homeobox 2	DiGeorge syndrome critical region gene 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Perinuclear Region Of Cytoplasm	Nucleus Extracellular Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of Transcription By RNA Polymerase II Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation	Cell Adhesion Animal Organ Morphogenesis
Pathways
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Postprandial triglyceride response ( 32603185) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		49 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 C9orf24 CARTPT CCDC196 CTAG1A CTAG1B DGCR6 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 PBX4 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SQSTM1 TBX2 TIMM10B TRIM25 TRIM42 VGLL1 ZNHIT3	66 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446
Entrez ID		4212	8214
HPRD ID		03443	03177
Ensembl ID		ENSG00000134138	ENSG00000183628
Uniprot IDs		A0A024R9L4 B3KP81 B3KPD8 B7Z6F6 O14770	Q14129 X5D7D2
PDB IDs		3K2A 4XRM 5BNG 5EG0
Enriched GO Terms of Interacting Partners?
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