MAL and HIBADH

Data Source:
BioGRID (two hybrid)

		MAL	HIBADH
Description		mal, T cell differentiation protein	3-hydroxyisobutyrate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Membrane Raft	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Central Nervous System Development Cell Differentiation Myelination Apical Protein Localization	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways			Branched-chain amino acid catabolism
Drugs			NADH
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35C2 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		4118	11112
HPRD ID		01789	12238
Ensembl ID		ENSG00000172005	ENSG00000106049
Uniprot IDs		A0A024RE19 P21145	A0A024RA75 P31937
PDB IDs			2GF2 2I9P
Enriched GO Terms of Interacting Partners?
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