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HIBADH and PLN
Data Source:
BioGRID
(two hybrid)
HIBADH
PLN
Description
3-hydroxyisobutyrate dehydrogenase
phospholamban
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Mitochondrion
Endoplasmic Reticulum
Membrane
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Molecular Function
Protein Binding
3-hydroxyisobutyrate Dehydrogenase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
NADP Binding
NAD Binding
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Biological Process
Valine Catabolic Process
Branched-chain Amino Acid Catabolic Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways
Branched-chain amino acid catabolism
Ion homeostasis
Ion transport by P-type ATPases
Drugs
NADH
Diseases
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Asthma (
31959851
)
Diastolic blood pressure (
27841878
)
General risk tolerance (MTAG) (
30643258
)
Kidney stones (
31729369
)
Lead levels in blood (
25820613
)
Pulse pressure (
27841878
)
Response to fenofibrate (HDL cholesterol levels) (
27002377
)
Systolic blood pressure (
27841878
)
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Interacting Genes
39 interacting genes:
ADAM33
AGTRAP
AIG1
AMELY
AQP3
ASGR1
BRCA1
C2CD2L
CDS2
CLEC2A
CMTM7
CNIH2
COMT
CTSA
EFNA5
ERMP1
GOSR2
MAL
NDUFB11
PAEP
PLN
PRAF2
PTCH1
RTP2
SCARB2
SEC22B
SFT2D2
SNORC
TFRC
TM6SF2
TMEM14B
TMEM222
TMEM60
TMEM86B
TRIM63
UBIAD1
VAMP2
VAMP5
ZFPL1
64 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
Entrez ID
11112
5350
HPRD ID
12238
01395
Ensembl ID
ENSG00000106049
ENSG00000198523
Uniprot IDs
A0A024RA75
P31937
P26678
Q5R352
PDB IDs
2GF2
2I9P
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
Enriched GO Terms of Interacting Partners
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