HIBADH and C2CD2L

Data Source:
BioGRID (two hybrid)

		HIBADH	C2CD2L
Description		3-hydroxyisobutyrate dehydrogenase	C2CD2 like
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Endoplasmic Reticulum Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Cytoplasmic Side Of Apical Plasma Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Protein Binding Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding Insulin Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Phospholipid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer
Pathways		Branched-chain amino acid catabolism
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	Heel bone mineral density ( 30598549)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	32 interacting genes: AQP6 ARL13B CD79A CHODL CISD2 CLRN1 CPEB2 CXCR3 EBP ELOVL5 EPB41 FCER1G GJA8 GJB1 HIBADH IL3RA MFSD5 MUC1 OPRM1 PDZK1IP1 REEP2 REEP4 SDCBP SLC10A6 SLC18A1 TMEM14B TMEM179B TMEM31 TMEM86B TMEM9 TMPRSS2 TMX2
Entrez ID		11112	9854
HPRD ID		12238	15533
Ensembl ID		ENSG00000106049	ENSG00000172375
Uniprot IDs		A0A024RA75 P31937	O14523
PDB IDs		2GF2 2I9P	5TOD
Enriched GO Terms of Interacting Partners?
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