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SMAD5 and MEN1
Data Source:
HPRD
(in vivo)
SMAD5
MEN1
Description
SMAD family member 5
menin 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Nuclear Matrix
Cleavage Furrow
Protein-containing Complex
Histone Methyltransferase Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
DEAD/H-box RNA Helicase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
I-SMAD Binding
Sequence-specific Double-stranded DNA Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Protein-macromolecule Adaptor Activity
Protein N-terminus Binding
R-SMAD Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Mullerian Duct Regression
Osteoblast Fate Commitment
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Cell Differentiation
Erythrocyte Differentiation
BMP Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Cardiac Muscle Contraction
Bone Development
SMAD Protein Signal Transduction
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Protein Phosphorylation
Osteoblast Development
DNA Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Cell Population Proliferation
Response To UV
Response To Gamma Radiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Histone Lysine Methylation
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Telomerase Activity
Beta-catenin-TCF Complex Assembly
Pathways
Signaling by BMP
Formation of the beta-catenin:TCF transactivating complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Deactivation of the beta-catenin transactivating complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate IQGAPs
Post-translational protein phosphorylation
Drugs
Diseases
Carcinoid
Adrenal carcinoma
Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
Malignant islet cell carcinoma
GWAS
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Mean platelet volume (
32888494
)
Sleep duration (short sleep) (
30846698
)
Urate levels (
21768215
)
Interacting Genes
46 interacting genes:
ACVR1
ANKRD13A
BCAT1
BMP6
CHMP3
COPS5
CXXC5
EP300
FLNA
GDF6
HBG2
HGS
HOXA13
HOXD13
MBD1
MEN1
MTMR10
NEDD4
PLEKHO1
PNKP
POU6F2
PPIL4
PSMD11
PTPN12
RBM4
RYR2
SF3B1
SF3B3
SFPQ
SMAD1
SMAD4
SMURF1
SMURF2
SNRNP70
SNRPA
SOX5
SOX7
SUV39H1
SUV39H2
TOB1
U2AF2
UBA1
WBP2
WWP1
ZEB2
ZNF8
32 interacting genes:
ASH2L
CTNNB1
DAXX
DBF4
ESR1
FANCD2
FOXN3
GFAP
H3-4
HDAC1
HDAC2
IQGAP1
JUND
KMT2A
KMT2D
MYC
MYH9
NFKB1
NFKB2
POLR2B
RBBP5
RELA
RPA2
SIN3A
SMAD1
SMAD3
SMAD5
SNW1
TCF3
TCF7L2
TP53
VIM
Entrez ID
4090
4221
HPRD ID
04381
00564
Ensembl ID
ENSG00000113658
ENSG00000133895
Uniprot IDs
Q68DB7
Q99717
A0A024R5D2
A0A024R5E3
A0A5F9ZHS3
O00255
Q9GZQ5
PDB IDs
6FZS
6TCE
3U84
3U85
3U86
3U88
4GPQ
4GQ3
4GQ4
4GQ6
4I80
4OG3
4OG4
4OG5
4OG6
4OG7
4OG8
4X5Y
4X5Z
5DB0
5DB1
5DB2
5DB3
5DD9
5DDA
5DDB
5DDC
5DDD
5DDE
5DDF
6B41
6BXH
6BXY
6BY8
6E1A
6O5I
6OPJ
6PKC
6WNH
Enriched GO Terms of Interacting Partners
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