SMAD5 and TOB1

Data Source:
HPRD (in vivo)

		SMAD5	TOB1
Description		SMAD family member 5	transducer of ERBB2, 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleus Cytoplasm CCR4-NOT Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Blood protein levels ( 28240269)
Interacting Genes		46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9
Entrez ID		4090	10140
HPRD ID		04381	09273
Ensembl ID		ENSG00000113658	ENSG00000141232
Uniprot IDs		Q68DB7 Q99717	P50616
PDB IDs		6FZS 6TCE	2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?
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