MED11 and GCSH

Data Source:
BioGRID (two hybrid)

		MED11	GCSH
Description		mediator complex subunit 11	glycine cleavage system protein H
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mediator Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Aminomethyltransferase Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Glyoxylate metabolism and glycine degradation Glycine degradation
Drugs			6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS			Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: ABI2 APP CCDC120 GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1	10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16
Entrez ID		400569	2653
HPRD ID		14709	01998
Ensembl ID		ENSG00000161920	ENSG00000140905
Uniprot IDs		I3L3E8 Q9P086	P23434
PDB IDs
Enriched GO Terms of Interacting Partners?
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