LCP1 and GCA

Data Source:
HPRD (in vitro, in vivo)

		LCP1	GCA
Description		lymphocyte cytosolic protein 1	grancalcin
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Phagocytic Cup Podosome Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Junction Filopodium Actin Filament Bundle Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Plasma Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding GTPase Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Extracellular Matrix Disassembly Cortical Actin Cytoskeleton Organization Animal Organ Regeneration Regulation Of Intracellular Protein Transport Interleukin-12-mediated Signaling Pathway Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Actin Filament Network Formation Actin Crosslink Formation Positive Regulation Of Podosome Assembly	Neutrophil Degranulation Membrane Fusion
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Neutrophil degranulation
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26502338)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: AIF1 ATXN2 CNN3 GCA PRKACA	15 interacting genes: ABHD11 ATXN1 BPIFA1 C10orf55 C11orf49 CALCOCO2 GSTO2 LCP1 MAGEA8 PSMB4 RBFOX1 SRI TRAF1 TRAF2 YPEL3
Entrez ID		3936	25801
HPRD ID		01082	06122
Ensembl ID		ENSG00000136167	ENSG00000115271
Uniprot IDs		A0A024RDT4 P13796	B7Z322 H7BXD5 P28676
PDB IDs		2D85 5JOJ 5JOL	1F4O 1F4Q 1K94 1K95
Enriched GO Terms of Interacting Partners?
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