LCP1 and AIF1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		LCP1	AIF1
Description		lymphocyte cytosolic protein 1	allograft inflammatory factor 1
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GO Annotations	Cellular Component	Stress Fiber Ruffle Phagocytic Cup Podosome Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Junction Filopodium Actin Filament Bundle Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Phagocytic Cup Nucleus Cytoplasm Cytosol Actin Filament Lamellipodium Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding GTPase Binding	Molecular_function Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Extracellular Matrix Disassembly Cortical Actin Cytoskeleton Organization Animal Organ Regeneration Regulation Of Intracellular Protein Transport Interleukin-12-mediated Signaling Pathway Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Actin Filament Network Formation Actin Crosslink Formation Positive Regulation Of Podosome Assembly	Microglial Cell Activation Phagocytosis, Engulfment Inflammatory Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Rac Protein Signal Transduction Actin Filament Polymerization Parallel Actin Filament Bundle Assembly Positive Regulation Of Cell Migration Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Cellular Response To Oxidative Stress Positive Regulation Of T Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Actin Filament Bundle Assembly Actin Crosslink Formation Cellular Response To Interferon-gamma Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Fibroblast Growth Factor Production Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26502338)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Crohn's disease ( 22936669) Heel bone mineral density ( 30598549) Height ( 23563607) Inflammatory bowel disease ( 28067908) Laryngeal squamous cell carcinoma ( 25194280) Malaria ( 31844061) Mean platelet volume ( 32888494) Neonatal lupus ( 20662065) Oral cavity cancer ( 27749845) Platelet count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Weight ( 19079260)
Interacting Genes		5 interacting genes: AIF1 ATXN2 CNN3 GCA PRKACA	2 interacting genes: ACTA1 LCP1
Entrez ID		3936	199
HPRD ID		01082	03496
Ensembl ID		ENSG00000136167	ENSG00000204472
Uniprot IDs		A0A024RDT4 P13796	I3WTX1 P55008 Q4V347
PDB IDs		2D85 5JOJ 5JOL	2D58 2G2B
Enriched GO Terms of Interacting Partners?
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