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KMT5A and BTRC
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
KMT5A
BTRC
Description
lysine methyltransferase 5A
beta-transducin repeat containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleoplasm
Chromosome
Cytosol
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Molecular Function
P53 Binding
Transcription Corepressor Activity
Protein Binding
Lysine N-methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity (H4-K20 Specific)
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Peptidyl-lysine Monomethylation
Histone H4-K20 Methylation
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Signal Transduction By P53 Class Mediator
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Mammary Gland Epithelial Cell Proliferation
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Rhythmic Process
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Cellular Response To Organic Cyclic Compound
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Condensation of Prophase Chromosomes
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
High density lipoprotein cholesterol levels (
29403010
)
Diastolic blood pressure (
30224653
)
Red blood cell count (
29403010
)
Red cell distribution width (
32888494
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
11 interacting genes:
BTRC
DTL
E2F2
FAM9A
H4-16
PCNA
TCF7L2
TP53
TWIST1
UBE2I
USP17L2
82 interacting genes:
AGO2
AMER1
ATF4
AXIN1
AXIN2
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CENPW
CHPF
CHUK
CP
CTNNB1
CUL1
DBN1
DEPTOR
DLGAP5
E2F1
FBXW11
FBXW2
FOXO3
FZR1
GHR
GLI2
GLI3
GSK3B
HIPK2
HNRNPC
HNRNPK
HNRNPU
ICE1
IL10RA
JUP
KDR
KMT5A
LPCAT1
MCL1
MDM2
MYB
MYC
NFE2
NFKB1
NFKB2
NFKBIA
NFKBIB
NHSL2
PAQR3
PCDH8
PDCD4
PER2
PLK4
PRDX1
PSMA3
PSMD4
RASSF5
RCAN1
RELA
RNF7
SKP1
SMAD3
SMAD4
SMURF1
SMURF2
SUFU
TACC1
TAZ
TIAM1
TP63
TRIB2
TRIM36
TRIM9
TSPAN15
UBC
UBE2D2
UBE2R2
UBQLN2
WEE1
XRCC1
ZC3H12A
Entrez ID
387893
8945
HPRD ID
06254
04596
Ensembl ID
ENSG00000183955
ENSG00000166167
Uniprot IDs
E3VVS3
Q9NQR1
A0A0S2Z4P6
B2R8L3
B7Z3H4
Q68DS0
Q9Y297
PDB IDs
1ZKK
2BQZ
3F9W
3F9X
3F9Y
3F9Z
4IJ8
5HQ2
5T5G
5TEG
5TH7
5V2N
5W1Y
6BOZ
1P22
2P64
6M90
6M91
6M92
6M93
6M94
6TTU
Enriched GO Terms of Interacting Partners
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