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KRT6B and NDC80
Data Source:
BioGRID
(two hybrid)
KRT6B
NDC80
Description
keratin 6B
NDC80 kinetochore complex component
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Keratin Filament
Extracellular Exosome
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Centrosome
Cytosol
Membrane
Ndc80 Complex
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Protein Binding
Identical Protein Binding
Biological Process
Cytoskeleton Organization
Ectoderm Development
Keratinization
Cornification
Mitotic Sister Chromatid Segregation
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Spindle Organization
Chromosome Segregation
Attachment Of Spindle Microtubules To Kinetochore
Centrosome Duplication
Cell Division
Metaphase Plate Congression
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Kinetochore Organization
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Protein Localization To Kinetochore
Pathways
Keratinization
Formation of the cornified envelope
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Metabolite levels (
23823483
)
Response to cognitive-behavioural therapy in major depressive disorder (
31123309
)
Interacting Genes
25 interacting genes:
GOLGA2
KDM1A
KIFC3
KRT13
KRT15
KRT19
KRT25
KRT27
KRT28
KRT31
KRT33B
KRT35
KRT37
KRT38
KRT39
KRT40
LINC00839
NDC80
NUP62
OIP5
SMARCB1
TEX11
TFIP11
TRIM54
TUBGCP4
64 interacting genes:
AMOTL2
ATF4
ATP5PO
ATP6V1D
AURKA
AURKB
BLOC1S6
CAGE1
CALCOCO1
CCDC136
CCHCR1
CCNH
CCNK
CENPH
CEP63
CKAP5
EPS15L1
EXOC8
FAM9C
GOLGA2
HAUS1
HGS
HIP1R
IFT20
INPP1
KIFC3
KLC3
KLHL12
KRT27
KRT6B
KRT75
LNX1
MAD1L1
MAD2L1
MFAP1
MIS12
NDE1
NDEL1
NEK2
NUF2
PCM1
PFDN1
PPP1R13B
PSMC2
RB1
RUFY4
SFR1
SGF29
SKA1
SMC1A
SPC25
STX11
TFIP11
THOC7
TNIP1
TOM1L1
TP53BP2
TXLNA
USHBP1
VPS52
WASHC1
WASHC3
ZNF655
ZWINT
Entrez ID
3854
10403
HPRD ID
01012
06277
Ensembl ID
ENSG00000185479
ENSG00000080986
Uniprot IDs
P04259
A8K031
O14777
PDB IDs
2IGP
2VE7
3IZ0
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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