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NDC80 and KLHL12
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
NDC80
KLHL12
Description
NDC80 kinetochore complex component
kelch like family member 12
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Centrosome
Cytosol
Membrane
Ndc80 Complex
Golgi Membrane
Cytosol
COPII Vesicle Coat
COPII-coated ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Centriolar Satellite
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Identical Protein Binding
Protein Binding
Identical Protein Binding
Biological Process
Mitotic Sister Chromatid Segregation
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Spindle Organization
Chromosome Segregation
Attachment Of Spindle Microtubules To Kinetochore
Centrosome Duplication
Cell Division
Metaphase Plate Congression
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Kinetochore Organization
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Protein Localization To Kinetochore
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Neural Crest Formation
Neural Crest Cell Development
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Degradation of DVL
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Response to cognitive-behavioural therapy in major depressive disorder (
31123309
)
Interacting Genes
64 interacting genes:
AMOTL2
ATF4
ATP5PO
ATP6V1D
AURKA
AURKB
BLOC1S6
CAGE1
CALCOCO1
CCDC136
CCHCR1
CCNH
CCNK
CENPH
CEP63
CKAP5
EPS15L1
EXOC8
FAM9C
GOLGA2
HAUS1
HGS
HIP1R
IFT20
INPP1
KIFC3
KLC3
KLHL12
KRT27
KRT6B
KRT75
LNX1
MAD1L1
MAD2L1
MFAP1
MIS12
NDE1
NDEL1
NEK2
NUF2
PCM1
PFDN1
PPP1R13B
PSMC2
RB1
RUFY4
SFR1
SGF29
SKA1
SMC1A
SPC25
STX11
TFIP11
THOC7
TNIP1
TOM1L1
TP53BP2
TXLNA
USHBP1
VPS52
WASHC1
WASHC3
ZNF655
ZWINT
62 interacting genes:
ARAF
ARRDC1
ATXN1
BAG6
BCL6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CRTC3
CUL3
DGCR6
DRD4
DVL1
DVL2
DVL3
FAM90A1
FBXL17
FGD2
FLNA
GLYCTK
INMT
KHSRP
KLHL2
KLHL24
KLHL3
LNPK
LNX1
MAPRE1
MED25
MED28
MPP1
MRPL10
MTNR1A
MYO15B
NDC80
NTAQ1
PDGFRB
PEA15
PEF1
PLEKHA4
PNKP
PRR13
RGL3
RIN1
RIT1
RNF4
RPP25L
SDCBP
SEC31A
SNX20
SYNE4
TAOK2
TBC1D10C
TCEANC
TTBK2
UBE2I
VEGFB
VTA1
ZBP1
ZBTB4
Entrez ID
10403
59349
HPRD ID
06277
13925
Ensembl ID
ENSG00000080986
ENSG00000117153
Uniprot IDs
A8K031
O14777
Q53G59
Q9H7R2
PDB IDs
2IGP
2VE7
3IZ0
2VPJ
6TTK
6V7O
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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