NDC80 and CKAP5

Data Source:
BioGRID (pull down)

		NDC80	CKAP5
Description		NDC80 kinetochore complex component	cytoskeleton associated protein 5
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Gamma-tubulin Complex Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Microtubule Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus End Polymerase
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centrosome Duplication Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	G2/M Transition Of Mitotic Cell Cycle Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656)
Interacting Genes		64 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CENPH CEP63 CKAP5 EPS15L1 EXOC8 FAM9C GOLGA2 HAUS1 HGS HIP1R IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PPP1R13B PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 THOC7 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT	11 interacting genes: ARHGEF16 AURKA CACNA1A CLASP1 CLK1 NDC80 PTPRN2 SLAIN2 SUMO2 TOP1 USP19
Entrez ID		10403	9793
HPRD ID		06277	10830
Ensembl ID		ENSG00000080986	ENSG00000175216
Uniprot IDs		A8K031 O14777	Q14008
PDB IDs		2IGP 2VE7 3IZ0	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?
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