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KIR2DL4 and RNF216
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
KIR2DL4
RNF216
Description
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
ring finger protein 216
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Early Endosome Membrane
Nucleus
Nucleoplasm
Cytosol
Schaffer Collateral - CA1 Synapse
Postsynaptic Endocytic Zone
Glutamatergic Synapse
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
MHC Class Ib Receptor Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Positive Regulation Of Natural Killer Cell Cytokine Production
Cellular Defense Response
Signal Transduction
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Immune Response
Positive Regulation Of Cellular Senescence
Apoptotic Process
Viral Process
Negative Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Defense Response To Virus By Host
Protein K48-linked Ubiquitination
Protein Catabolic Process, Modulating Synaptic Transmission
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Objective response to lithium treatment (
26503763
)
Interacting Genes
9 interacting genes:
BPIFA1
FCER1G
FHL5
HLA-G
INCA1
RBPMS
RNF216
TIMMDC1
TRIP6
30 interacting genes:
AGFG1
BRCA1
CAPN15
FAM168A
KIR2DL4
MAPK1
MORC3
OPTN
RIPK1
RNF11
SUMO2
TLR3
TLR4
TLR5
TLR9
TNFAIP3
TRAF3
UBAC1
UBASH3A
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2L3
UBE2L6
USP5
YOD1
ZFAND2A
Entrez ID
3805
54476
HPRD ID
16082
15550
Ensembl ID
ENSG00000189013
ENSG00000011275
Uniprot IDs
A0A0B4J1S6
A0A376A929
Q99706
A8K8N1
Q9NWF9
PDB IDs
3WYR
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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