KCNN3 and HAX1

Data Source:
BioGRID (proximity labelling technology)

		KCNN3	HAX1
Description		potassium calcium-activated channel subfamily N member 3	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	Calmodulin Binding Small Conductance Calcium-activated Potassium Channel Activity	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Ion Transport Potassium Ion Transmembrane Transport	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Ca2+ activated K+ channels
Drugs		Procaine Miconazole Trimebutine
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416818 29290336 30061737 29892015 20173747 22544366) Bipolar disorder ( 31043756) Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) Incident atrial fibrillation ( 28416818) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Prevalent atrial fibrillation ( 28416818) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 28552196)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: APP CALM1 CLCN7 EMD ERMP1 FCER1G NAPB	25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420
Entrez ID		3782	10456
HPRD ID		04283	12075
Ensembl ID		ENSG00000143603	ENSG00000143575
Uniprot IDs		A0A087WYJ0 Q9UGI6	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs
Enriched GO Terms of Interacting Partners?
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