KCNN3 and CLCN7

Data Source:
BioGRID (two hybrid)

		KCNN3	CLCN7
Description		potassium calcium-activated channel subfamily N member 3	chloride voltage-gated channel 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Calmodulin Binding Small Conductance Calcium-activated Potassium Channel Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Ion Transport Potassium Ion Transmembrane Transport	Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Ca2+ activated K+ channels	Stimuli-sensing channels
Drugs		Procaine Miconazole Trimebutine
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416818 29290336 30061737 29892015 20173747 22544366) Bipolar disorder ( 31043756) Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) Incident atrial fibrillation ( 28416818) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Prevalent atrial fibrillation ( 28416818) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 28552196)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: APP CALM1 CLCN7 EMD ERMP1 FCER1G NAPB	17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		3782	1186
HPRD ID		04283	04103
Ensembl ID		ENSG00000143603	ENSG00000103249
Uniprot IDs		A0A087WYJ0 Q9UGI6	P51798
PDB IDs			7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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