DNAJB13 and PLK4

Data Source:
BioGRID (two hybrid)

		DNAJB13	PLK4
Description		DnaJ heat shock protein family (Hsp40) member B13	polo like kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Axoneme Motile Cilium Sperm Flagellum Sperm Connecting Piece	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Protein Binding Unfolded Protein Binding Chaperone Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Chaperone Cofactor-dependent Protein Refolding Axonemal Central Apparatus Assembly	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS		Dimensional psychopathology (Cognitive) ( 29496196)
Interacting Genes		12 interacting genes: GORASP2 LHX4 MDFI MSS51 PIBF1 PICK1 PLK4 RAB3IP SEPTIN1 TOM1L1 ZC3H12A ZRANB1	22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		374407	10733
HPRD ID		15573	10387
Ensembl ID		ENSG00000187726	ENSG00000142731
Uniprot IDs		P59910	O00444
PDB IDs			2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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