JUND and MEN1

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, in vivo)

		JUND	MEN1
Description		JunD proto-oncogene, AP-1 transcription factor subunit	menin 1
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Protein-DNA Complex Transcription Factor AP-1 Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Nuclear Receptor Binding Enzyme Binding Sequence-specific Double-stranded DNA Binding	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding
	Biological Process	Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Aging Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Response To Organic Cyclic Compound Response To Lipopolysaccharide Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Calcium Ion	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly
Pathways		Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation
Drugs
Diseases			Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma
GWAS		Autoimmune thyroid disease ( 32581359) Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Systemic lupus erythematosus ( 33536424) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)	Urate levels ( 21768215)
Interacting Genes		30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 LINC00461 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP	32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM
Entrez ID		3727	4221
HPRD ID		01304	00564
Ensembl ID		ENSG00000130522	ENSG00000133895
Uniprot IDs		P17535	A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5
PDB IDs		3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH
Enriched GO Terms of Interacting Partners?
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