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NEDD4 and HNRNPK
Data Source:
BioGRID
(pull down)
NEDD4
HNRNPK
Description
NEDD4 E3 ubiquitin protein ligase
heterogeneous nuclear ribonucleoprotein K
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Protein-containing Complex
Dendritic Spine
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Chromatin
Podosome
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Cytoplasmic Stress Granule
Membrane
Cell Projection
Extracellular Exosome
Catalytic Step 2 Spliceosome
Molecular Function
Protein Binding
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ubiquitin Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Cadherin Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Macroautophagy
Protein Ubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
MRNA Splicing, Via Spliceosome
Regulation Of Transcription By RNA Polymerase II
RNA Processing
Signal Transduction
Regulation Of Gene Expression
Regulation Of Low-density Lipoprotein Particle Clearance
Viral Process
RNA Metabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Low-density Lipoprotein Receptor Activity
Pathways
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
SUMOylation of RNA binding proteins
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
HCMV Late Events
Drugs
Artenimol
Phenethyl Isothiocyanate
Diseases
GWAS
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Stroke (
29531354
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Triglyceride levels (
32203549
)
Interacting Genes
238 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BMPR1A
BRCA2
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA
GFUS
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IFITM3
IGF1R
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
LAPTM5
LATS1
LINC01198
LITAF
LUC7L2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RET
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUNX1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SERTAD1
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THOC1
THRAP3
TNIK
TOM1
TOM1L2
TP53BP2
TP73
TRIM44
TRIM52
TRPV6
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
220 interacting genes:
ABI1
ABI2
ADRB2
ANKRD28
APBB1
APOBEC1
APOBEC3C
AQP5
AURKA
BTRC
C6orf223
C6orf226
CBLB
CCAR1
CCDC187
CCDC33
CDKN1A
CEBPB
CIRBP
CMTM5
CNNM3
CSK
CTNNBL1
DALRD3
DDX1
DDX17
DDX5
DHX9
DIDO1
DOCK2
DUX4
EIF3F
ELAVL1
ETNK2
FBXL18
FBXO7
FBXW7
FOXD4L1
FOXD4L3
FYN
GFI1B
GRAP2
GRB2
GZMA
GZMK
H3-4
HBZ
HCK
HMGB1
HNRNPA0
HNRNPL
HNRNPLL
IRGC
ITK
ITSN2
KCTD8
KHDRBS1
KHDRBS2
KHDRBS3
KLF1
LYN
MAP2K2
MAPK10
MARK4
MATR3
MDM2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MISP
MRPL9
MYPOP
NCK2
NEDD4
NOTO
NPDC1
PABPC1
PCBP1
PCBP2
PCDHB14
PCGF3
PELI2
PGAP6
PIN1
PPP1R10
PRKCD
PRMT1
PRPF31
PRPF40A
PRR3
QKI
RALY
RAMAC
RASAL3
RASD1
RBFOX2
RBM10
RBM14
RBM3
RBM4
RBM41
RBM42
RBM7
RBMX
RBMY1A1
RBMY1F
RBMY1J
RBPMS2
RNA18SN5
RNA28SN5
RNF4
RPH3AL
RTP5
SAFB
SF1
SMAD3
SNRPA
SORBS3
SPG7
SRC
SREK1
SRPK2
SRRT
SRSF3
SUMO1
SUMO2
SYNCRIP
TBP
TCERG1
TCF23
TERF2IP
TH
TLE5
TYK2
U2AF1
U2AF1L5
UBE2I
VAV1
WBP4
WWOX
YBX1
YTHDC1
YWHAQ
ZFC3H1
ZNF385C
ZNF408
ZNF526
ZNF575
ZNF688
ZNF792
ZNRF2P1
Entrez ID
4734
3190
HPRD ID
03786
02834
Ensembl ID
ENSG00000069869
ENSG00000165119
Uniprot IDs
P46934
B4DUQ1
P61978
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
1J5K
1KHM
1ZZI
1ZZJ
1ZZK
Enriched GO Terms of Interacting Partners
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